Sophia L. Zagora, Dilraj Grewal, Julijana Baltinas, Sue Lightman, Oren Tomkins-Netzer
Purpose: To investigate whether the area of foveal avascular zone (FAZ), vessel density (VD) in the superftcial capillary plexus (SCP) and deep capillary plexus (DCP), extent of disorganization of retinal inner layers (DRIL) and size of the intraretinal cyst (IRC) on en face imaging using optical coherence tomography angiography (OCTA) correlates with corrected visual acuity (VA) in eyes with non- infectious CME.
Methods: Cross-sectional study of 32 eyes of 26 patients (13 female) with CME (central subfteld thickness >320?m) who underwent treatment with either periocular triamcinolone (40mg/0.1mL), intra- vitreal triamcinolone 4mg or 0.7mg Ozurdex. Base- line and follow up B scan and en face OCT images, and 3×3 mm OCTA images (Zeiss Angioplex) cen- tered on the fovea were analyzed.
Results: Mean baseline VA (ETDRS letters) was
38.1 and at last post treatment follow up was 37.9 (p=0.8). Baseline VA (ETDRS letters) positively cor- related with the VD in the SCP (0.61, p=0.09) and DCP (r=0.65, p=0.08). There was a negative correla- tion of FAZ area in the SCP (r=-0.53, p=0.04) and DCP (r=-0.42, p=0.2) with VA. Extent of DRIL in the central 1000 ?m foveal area (r=-0.54, p=0.05) and IRC area on en face OCT (r=-0.62, p=0.05) at baseline correlated negatively with vision. Follow- ing treatment, there was a 52.9% reduction in DRIL at ftnal follow-up.
Conclusion: Using OCTA, VD and FAZ in the SCP and DCP correlated with VA. DRIL and IRC size negatively correlated with VA indicating that these vascular and structural changes on OCTA could potentially serve as a non-invasive surrogate bio- markers for VA.