ABSTRACT NUMBER - 1208

COMPARATIVE EVALUATION OF AMNIOTIC MEMBRANE TRANSPLANTATION ALONE VERSUS CULTIVATED LIMBAL STEM CELL TRANSPLANTATION IN CASES OF PARTIAL LIMBAL STEM CELL DEFICIENCY (LSCD)


Rasik Vajpayee, Namrata Sharma, Sujata Mohanty

Meeting:  2012 RANZCO


SESSION INFORMATION

Date: 26 Nov 2012

Session Title: FREE PAPERS

Session Time: 2:00 pm - 3:30 pm

Purpose:
Comparative evaluation of amniotic mem-brane transplantation alone versus cultivated limbal stem cell transplantation in cases of partial limbal stem cell deficiency (LSCD) due to chemical burns.

Methods:
Randomized controlled clinical trial was conducted on 40 eyes of 40 patients with unilateral partial LSCD caused by chemical burn. Amniotic mem-brane transplantation alone or cultivated Limbla stem cell (from fellow eye) transplantation was done in 20 eyes each and followed up for one year. The param-eters evaluated were corneal conjunctivalization, vas-cularization, corneal clarity and best corrected visual acuity at 1, 3, 6 and 12 months after surgery.

Results:
At the end of one year there was no differ-ence in terms of conjunctivalization (p = 0.06), vascu-larization (p = 0.08) and corneal clarity (p = 0.07) in the two groups. 65% achieved BCVA of 20/40 or better in the amniotic membrane transplantation group in comparison to 68 % in the cultivated limbal stem cell transplantation group. Pyogenic granuloma were present in two eyes in the amniotic membrane trans-plantation group and one eye in the cultivated group for which repeat amniotic membrane transplantation was done.

Conclusion:
Amniotic membrane transplantation alone is a useful therapeutic modality in cases of partial LSCD due to chemical injury. Cultivated stem cell transplantation may not be required in these cases.