Rasik Vajpayee, Namrata Sharma, Sujata Mohanty
Comparative evaluation of amniotic mem-brane transplantation alone versus cultivated limbal stem cell transplantation in cases of partial limbal stem cell deficiency (LSCD) due to chemical burns.
Randomized controlled clinical trial was conducted on 40 eyes of 40 patients with unilateral partial LSCD caused by chemical burn. Amniotic mem-brane transplantation alone or cultivated Limbla stem cell (from fellow eye) transplantation was done in 20 eyes each and followed up for one year. The param-eters evaluated were corneal conjunctivalization, vas-cularization, corneal clarity and best corrected visual acuity at 1, 3, 6 and 12 months after surgery.
At the end of one year there was no differ-ence in terms of conjunctivalization (p = 0.06), vascu-larization (p = 0.08) and corneal clarity (p = 0.07) in the two groups. 65% achieved BCVA of 20/40 or better in the amniotic membrane transplantation group in comparison to 68 % in the cultivated limbal stem cell transplantation group. Pyogenic granuloma were present in two eyes in the amniotic membrane trans-plantation group and one eye in the cultivated group for which repeat amniotic membrane transplantation was done.
Amniotic membrane transplantation alone is a useful therapeutic modality in cases of partial LSCD due to chemical injury. Cultivated stem cell transplantation may not be required in these cases.