ABSTRACT NUMBER - S3702

CORNEAL REMODELLING FOLLOWING CATARACT SURGERY: OCT ANALYSIS OF THE EFFECT OF INCISION SIZE ON WOUND ARCHITECTURE IN THE THREE MONTHS FOLLOWING SURGERY


Sunny Li, Stuti Misra, Charles McGhee, Henry Wallace, James McKelvie

Meeting:  2017 RANZCO


Purpose: To characterise wound healing and cor- neal incision architecture with different keratome sizes in the three months following cataract surgery. Method: A prospective randomised study of 95 patients undergoing cataract surgery assigned to uniplanar clear-corneal temporal incision sizes of 2.20mm or 2.85mm was completed following formal ethics review. Incision position, length, angle, and leakage were recorded, in combination with total ultrasound energy and corneal thickness. Corneal topography and incision imaging using OCT was completed at one day, one week, one month and three months, postoperatively. Statistical analysis was completed using R statistical software.
Results: Endothelial wound gaping was observed in 63% (2.20mm keratome) and 45% (2.85mm kera- tome), p-value=0.03. Descemet?s membrane detach- ments were observed in 57% (2.2mm keratome) and 40% (2.85mm keratome), p-value=0.01. Increasing phacoemulsiftcation time was associated with Descemet?s membrane detachment (p- value=0.02), endothelial wound gaping (p- value=0.03) and increased wound thickness (p- value=0.02). Endothelial wound gaping improved within the ftrst month and wound retraction pro- gressed from one to three months following surgery. Wound leakage was noted only in one case (incision angle=35.0o), overall mean incision angle was 25.1 4.6o.
Conclusion: Increasing ultrasound energy and smaller incisions are associated with wound gaping and retraction that demonstrate corneal remodelling over three months following cataract surgery. Smal- ler incisions are associated with increased rates of Descemet?s membrane detachment and increased localised corneal thickness in the postoperative period. Uniplanar incisions of 2.2mm and 2.85mm can be consistently constructed, do not leak and typ- ically do not require hydration.