ABSTRACT NUMBER - L06

Involvement of the vascular endothelium in uveitis


Associate Professor Justine Smith, FRANZCO

Meeting:  2011 RANZCO


SESSION INFORMATION

Date: 22 Nov 2011

Session Title: IDA MANN LECTURE

Session Time: 10:30 am - 11:00 am

Uveitis poses a high annual cost to society, primarily because more cases begin during the working years than at any other period in life. Present treatments are crude. We use potentially toxic forms of systemic immunosuppression that fail to target the eye specifically. Even new local therapies act relatively non-specifically. More effective and safer future biologic therapies will target the molecular and cellular mediators of the inflammation. For uveitis to be manifest, the ocular vascular endothe-lium must permit leukocytes or microbes to cross from the circulation into the eye. Movement is controlled by molecules expressed on the endothelium. Our research focuses on identifying these molecular mediators and evaluating their potential as new targets for highly specific therapies of uveitis

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