ABSTRACT NUMBER - 140

OCULAR TOXOPLASMOSIS IN A LARGE TERTIARY REFERRAL CENTRE IN SYDNEY, AUSTRALIA


William Yatez, Sophia Zagora, Richard Symes, Denis Wakefteld, Peter McCluskey

Meeting:  2017 RANZCO


SESSION INFORMATION

Date:      -

Session Title: UVEITIS - Poster Abstracts

Session Time:      -

Purpose: to determine the epidemiology, clinical features, diagnostic and therapeutic options as well as visual morbidity associated with acquired ocular toxoplasmosis infection in Australia.
Method: a retrospective cohort of patients with chorioretinitis due to ocular toxoplasmosis. Baseline demographics including age, country of birth, immune status and pregnancy status was recorded. Vision was recorded in LogMAR. The chorioretinitis was graded using the SUN classiftcation included the grading of anterior cells, vitritis and the location of the lesions in relation to the macula. Treatment modalities including topical, systemic corticosteroids and antimicrobials agents were included for analysis.
Results: 42 patients (44 eyes) were included in this study from 2007 to 2017. The median age was 35.5 (IQR 21-50) with 26 (62%) with no previous symp- tomatic episodes or evidence of chorioretinal scar- ring. Laboratory testing was not routinely used nor helped with positive predictive value. Visual acuity at presentation was 0.51 6/19 (SE 0.096) and at fol- low up 0.31 or 6/9 (SE (0.094). 9 patients experi- enced a recurrence during the period of observation with time to recurrence 2.2 years (SE 0.45). The relapse rate (1 or more) 0.09/person-year. Location of lesion was predominantly within the vascular arcades (n=23) with macular involvement in 9 patients. Most patients received clindamycin ther- apy (n=30) with pyrimthamine + sulfadiazine used for those with macula involvement.
Conclusions: ocular toxoplasmosis in Australia appears to be a milder disease than other parts of the world. Most patients received antimicrobial therapy and systemic corticosteroids especially if there was activity within the vascular arcades. Reac- tivation rate was low in this cohort during the period of observation.

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