Chi Yun Doreen Ho, Jia Jia Lek, Khin Zaw Aung, Myra McGuinness, Chi Luu, Robyn Guymer
Purpose: Several recent studies have shown that eyes with various stages of age-related macular degeneration and reticular pseudodrusen (RPD) are associated with thinner choroids and greater risk of progression to advanced AMD. The purpose of our study is to investigate the relationship between cho- roidal thickness (ChT) and reticular pseudodrusen (RPD) in a large cohort of eyes with intermediate AMD (iAMD), controlling for variables such as age, gender, refractive error and smoking.
Method: Colour fundus photographs (CFP), fundus auto ?uorescence (FAF), near infrared (NIR) and spectral-domain optical coherence tomography (SD- OCT) were graded for RPD. ChT was measured from enhance depth imaging OCT scans at the cen- tre of fovea, 1500 ?m and 3000 ?m nasal, temporal, superior and inferior from centre of fovea.
Results: 152 subjects (304 eyes) were included in this analysis. 84 (28%) had RPD and 213 (70%) had no RPD. RPD subjects were older than non-RPD (75.1 5.4 years and 68.7 6.9 years, respectively; p< 0.001). In unadjusted analysis, the RPD group had signiftcantly thinner choroids across all measured locations (p ? 0.022) than non-RPD group. After adjusted for variables, the presence of RPD was no longer associated with ChT (p ? 0.132 for retinal all locations) but age (p < 0.001) and refractive error (p < 0.001) remained signiftcantly associated with ChT. Conclusions: Age and refractive error, rather than RPD, was signiftcantly associated with choroidal thinning in this cohort of iAMD eyes.