Mangat Dogra, Ramanuj Samantha, Deeksha Katoch, Mohit Dogra, Savleen Kaur, Mansi Sharma
Purpose: Early treatment retinopathy of prematurity (ETROP) study evaluated infants below 1250 grams at birth. However, aggressive posterior retinopathy of prematurity (APROP) is reported in heavier babies in developing countries. The aim of this study was to analyze the spectrum of disease and structural outcome in APROP eyes treated with laser photocoagulation in the last 10 years from a tertiary care centre of a developing country.
Methods: Retrospective, consecutive, interventional case series. Ten years retrospective analysis of APROP in 195 eyes of 100 infants treated with laser photocoagulation.
Results: Mean birth weight was 1404.3grams (range 700-2600) and mean period of gestation 30 weeks (range 25-38). One hundred and thirty six of 195 eyes (69.7%) showed classic APROP and 59 (30.3%) atypical variant or hybrid ROP which is mixture of classic APROP with ROP stage formation and/or matt like proliferation. Sixty nine of 195 eyes (35.4%) had zone1 and 126 (64.6%) posterior zone 2 disease. Mean time of laser treatment was 35.6 days (range 17-90) after birth. Favourable structural outcome was achieved in 174 eyes (89.2%) with confluent laser photocoagulation.
Conclusion: Aggressive posterior retinopathy of prematurity may occur in higher birth weight babies in developing countries. Spectrum of disease is different with majority involving posterior zone 2 which is contrary to earlier reports from developed countries. High success rate with early laser photocoagulation observed in this study may be related to higher birth weight of babies and posterior zone 2 involvement in large number of babies.