Matthew Simunovic1 ,4, Kanmin Xue1 ,2, Jasleen Jolly1 ,2, Robert MacLaren1,2
Purpose: To study the short term effects of iatrogenic macula detachment in patients with well-preserved visual function.
Methods: Five participants aged 23-71 yr, with visual acuities from 39 to 70 letters, were recruited from a Phase I/II trial of gene therapy for choroideremia (ClinicalTrials.gov NCT01461213). Subjects underwent unilateral sub-retinal injection of 0.1mL of a solution containing 1011 AAV2.REP1 particles. Patients were assessed prior to surgery with follow-up at 1 day, 1 week and 1 month following surgery. Structure was assessed by spectral-domain OCT and function by visual acuity, microperimetry, colour discrimination (FM 100Hue) and colour matching (Rayleigh match).
Results: Sub-retinal fluid was eliminated by day 1. No evidence of change in central foveal thickness was found (change in CFT +9.6 ± 7.2 ?m in treated eyes versus +8.8 ±12.6 ?m in control eyes at 1 month). Visual acuity recovered to baseline by 1 month (change +5.4 ± 3.3 letters and +0.8 ± 3.1 letters in treated and control eyes respectively) . In one subject, pseudoprotanomaly was observed at the Rayleigh match, indicating decreased cone photopigment optical density. This finding was accompanied by a loss of tritan color discrimination at the FM100Hue and persisted at 1 month.
Conclusions: The iatrogenic macula detachment performed as part of gene therapy in this study recovered by day 1 and did not appreciably affect central foveal thickness. Whilst visual acuity and threshold sensitivity recovered by 1 month, subtle alterations in color matching – suggestive of decreased cone photopigment optical density – may persist.
GLISTENINGS IN INTRAOCULAR LENSES IN AUSTRALIA AND NEW ZEALAND- A COLLABORATIVE SURGICAL QUALITY AUDIT OVER THE 24 MONTH PERIOD UP TO FEBRUARY 2017. FINDINGS OF THIS AUDIT OF LENSES IMPLANTED BETWEEN 1995 AND 2016, HIGHLIGHT THE ONGOING PRESENCE AND SEVERITY OF VACUOLES EVEN IN THE MOST RECENTLY IMPLANTED LENSES.