Vannessa Leung, Stephanie Watson
Purpose. Hypertonic saline 5% eye drops may be prescribed for corneal oedema, however they are expensive, not routinely available and have little human data supporting their efftcacy. The aim of study was to determine indications for and out- comes of hypertonic saline eye drops at the Sydney Eye Hospital.
Methods. A retrospective case series was con- ducted. The pharmacy database was interrogated for patients receiving hypertonic eye drops 5% from January 2011 to December 2016. Data collated from case notes included patient demographics, ocular and medical history, indication and dosage of hyper- tonic saline, clinical signs/symptoms at baseline and ftnal visit (last recorded or pre-transplantation appointment) and concurrent medications. Pearson?s coefftcient was used to correlate variables.
Results. 182 eyes from 150 patients were included, mean age was 68 years (range 12 to 98) and 84 were male. The indications for hypertonic saline included corneal oedema (n =162 eyes, 89%), corneal hydrops (n=10, 5%) and corneal ulcer (n=2, 1%). Duration of treatment averaged 601 days (range 2 to 6026). 58 eyes (32%) underwent corneal transplan- tation (49 DSEK, 9 PK). Of the 124 eyes not having corneal transplants, baseline visual acuity (0.76
0.77 logMAR) was not signiftcantly different to that post-treatment (0.83 0.71, p=0.278). Increasing duration (-0.117, p<0.01) and frequency (-0.104, p=0.012) of hypertonic saline use signiftcantly corre- lated with improved visual acuity. No adverse events were reported. Conclusion. Hypertonic saline eye drops are most commonly indicated for corneal oedema. Improve- ment in visual acuity was associated with increased duration and frequency of their use.