Christopher Go1, Jane Foo1, Samantha Bobba1, Jay Chandra1, Adrian Fung1,2,3
Background : Endophthalmitis is a devasting and potentially blinding condition. With the increasing use of intravitreal injection, it is postulated that there is a changing trend in its aetiology.
Method: Microbiology records were reviewed of all vitreous samples at Westmead Hospital sent between September 2009 to August 2017.
Result : 234 vitreous samples were received during this period. 45 had positive microscopy. 10 cases were excluded after reviewing medical records;
3 were not endophthalmitis clinically, 1 was an anterior chamber tap and 6 did not have growth after incubation. 30 of the 35 included cases had exogenous causes and 5 were endogenous. In the exogenous group, 21 were intravitreal injection related, 8 have had ocular surgery and 1 had an associated keratitis. In the endogenous group, 2 were septic, 2 were immunosuppressed and 1 was an intravenous drug user.
At presentation, 4 had visual acuity better than 6/60, 22 were CF/HM, 8 were LP and 1 NPL. All 35 cases had vitreous sampling on day of presentation; 34 from tap-and-inject and 1 from vitrectomy.
The most common organism was coagulase negative staphylococcus (n = 16). Other organisms include strep species (n = 5), staphylococcus aureus (n = 4), candida species (n = 2), mixed species (n = 2) and other species (n = 6).
At 1 year follow-up, 13 had visual acuity greater than 6/60, 8 were 6/60 or worse, 7 were NPL and 9 were lost to follow up.
Discussion: The incidence of culture proven endophthalmitis was low and the most common susceptible organism is coagulase negative staphylo- coccus, consistent with current literature.
COMPARISON OF RANIBIZUMAB AND AFLIBERCEPT IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATED FOLLOWING A ?TREAT AND EXTEND? PROTOCOL: EFFICACY VARIABLES FROM THE PRE-SPECIFIED 12- MONTH INTERIM ANALYSIS OF THE RIVAL STUDY