ABSTRACT NUMBER - 13

A RANZCO POSITION STATEMENT ON OCULAR STEM CELL THERAPY


Samantha Bobba1,2, Nick Di Girolamo3, Megan Munsie4, Fred Chen5, Alice Pebay6, Damien Harkin7, Alex Hewitt8, Michael O’Connor9, Samuel McLenachan10, Audra Shadforth7, Stephanie Watson11,12,1

Meeting:  2018 RANZCO


SESSION INFORMATION

Date:      -

Session Title: POSTER ABSTRACT- Cornea

Session Time:      -

Purpose: A greater understanding of the function and location of ocular stem cells (SCs) has led to rapid advances in possible therapeutic applications. However, ocular SC therapy is associated with sig- nificant technical challenges and potential long-term complications. Whilst other international organisa- tions have developed guidelines regarding the use of ocular SC therapy, a RANZCO position statement does not yet exist. Our purpose was to develop a position statement on the role of ocular SC therapy from an Australian perspective in the context of international advances.
Methods: A systematic literature review of ocular SC therapy was conducted, registered clinical trials reviewed and expert opinions sought. Collated data was used to develop a position statement based on current guidelines whilst also considering activities occurring outside the expected pathways to clinical translation.
Results: This position statement supports advance- ments in knowledge, whilst endeavouring to mini- mise patient harm. The literature suggests that limbal epithelial progenitor cells for ocular surface transplantation are a viable therapy based on Phase I/II clinical trials, and that the development of more robust clinical trials is reasonable. Further pre- clinical evaluation and/or clinical trials of all other cellular-based interventions that rely on induced pluripotent SCs, human embryonic SCs, mesenchy- mal SCs and other potential SC sources are required.
Conclusion: Expert opinion and systematic review of the safety and efficacy of ocular SCs were used to develop a position statement on ocular SC therapy. This has recently been approved by the RANZCO Board as the college’s first position statement on the topic.