Phingphan Klongthanakit, Patama Bhurayanontachai
Purpose: To investigate patient characteristic, clinical features, common organisms and visual acuity outcomes associated with endogenous endophthalmitis.
Methods: A retrospective chart review of 24 patients diagnosed as endogenous endophthalmitis from January 2006 to July 2015. Data information included basic characteristics, host status, presenting symptoms, causative organisms, treatment and visual acuity outcomes
Results: Twenty-six eyes of 24 patients were included in the study. Mean age of the patients was
45.75 years old, and 62.5% of them were female. Presenting visual acuities ranged from 1.7 to 3.0 log- MAR. Identiftable risk factors were present in 45.8%, with the majority related to diabetes mellitus. Septicemia was the most common infection source. All cases were culture positive. Positive culture was 68.18% in systemic samples and 76% in intraocular samples. Of our cases, gram-positive bacteria were identifted in 14 cases (50%), gram- negative bacteria in 8 cases (28.57%), and fungus in 6 cases (21.43%). Streptococcus species, a gram positive organism, was the most responsible causative organism for endogenous endophthalmitis Final Snellen acuities ranged from 0.4 to 3.0 logMAR. A total of 12 out of 26 eyes were eviscerated or enucleated, 13 eyes were vitrectomy.
Conclusion: This study difference from previous Asian studies ftndings, showed that Streptococcus spp. was the most common causative organism of endogenous endophthalmitis and septicemia was the most common infection focus. Although endogenous endophthalmitis is generally associated with poor visual acuity outcomes, Prompt treatment with intravitreal antibiotics and vitrectomy can result in improvement in ocular signs and visual acuity in majority of the patients.
COMPARISON OF RANIBIZUMAB AND AFLIBERCEPT IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATED FOLLOWING A ?TREAT AND EXTEND? PROTOCOL: EFFICACY VARIABLES FROM THE PRE-SPECIFIED 12- MONTH INTERIM ANALYSIS OF THE RIVAL STUDY