Joos Meyer, Roshan Karri, Helen V. Danesh-Meyer, Kate Drummond, Andrew Symons

Purpose: Develop the first normative database of standard macular and circumpapillary optical coherence tomography (OCT) scans at the level of the A-scan using the Heidelberg Spectralis machine. This study aims to help clinicians and researchers identify abnormal pat- terns of change through a normative database, smart phone application and open access dataset.

Methods: A retrospective cross sectional analysis of OCT scans of healthy individuals. All participants had a full ophthalmic examination, including best corrected visual acuity, intra ocular pressure, biomicroscopy, posterior segment examination and OCT scan. The volume and thickness of each of the nine Early Treatment Diabetic Retinopathy zones at the macula were analysed for the total retinal thickness, retinal nerve fibre layer, ganglion cell layer (GCL) and inner plexiform layer (IPL). The circumpapillary retinal nerve fibre layer thickness. Associations between age, gender, refractive error and OCT measurements were explored. A smart phone application was created for clinical use. A-scans were extracted from the OCT machine and made available as an open access database.

Results: Two-hundred eyes from 146 participants, mean age (SD) 48.52 (17.52), 69 (47%) female were included. The mean retinal, GCL and IPL volumes were significantly greater in males than females. Age and total retinal volume (r = –0.2561, p = 0.0003), GCL volume (–0.2911, p < 0.0001) and IPL volume (–0.3194, p < 0.0001) were negatively correlated. Smart phone application http://normdb.com/ and open access database https://doi.org/10.6084/m9.figshare. 14794839 Conclusion: This study provides a normative database Heidelberg Spectralis OCT scans which may provide clinical utility for identifying abnormal patterns of change.