Seung Yong Choi, Young-Hoon Park
Purpose: To investigate the association between oral ﬂuoroquinolones and the risk of rhegmatogen- ous retinal detachment (RRD) by a population- based study in Korea.
Methods: Using the KNHIS-NSC (Korean National Health Insurance Service National Sample Cohort) 2002-2013 data, a nested case-control study was per- formed. The subjects who visited an ophthalmologist were deﬁned as a cohort, excluding subjects with infec- tious retinitis, ocular trauma, or congenital diseases. Subjects who underwent surgery for RRD within deﬁned cohort were deﬁned as cases, and controls were matched by age group, sex, and cohort entry date by an incidence density sampling method. By an inves- tigation of the exposure of ﬂuoroquinolone, the odds ratio was calculated and adjusted by the confounding factors. Subgroup analysis based on the interval between the index date and day of exposure to ﬂuoro- quinolone was done (subgroups with 0-14, 15-90, 91-180, 181-270, and 271-365 days after exposure).
Results: A total of 1,151 subjects in the case group and 11,470 subjects of a matching control group was included. There were signiﬁcant differences in household income, numbers of ophthalmologic visits and drug prescriptions, events of intraocular surgeries, and prevalence of diabetes and degenera- tive myopia between the case and control group (all P’s < 0.05). The crude odds ratio was 1.06 (P = 0.53, 95% CI 0.88-1.28), and the adjusted odds ratio adjusted was 1.00 (P = 0.99, 95% CI 0.81-1.24). There were no statistical signiﬁcance in crude and adjusted odds ratios of subgroups (all P’s > 0.05).
Conclusions: By a nested case-control study, oral administration of FQ was not associated with the risk of RRD.