Purpose: To describe eyelid clicking, a previously undescribed side effect of prostaglandin F2-alpha agonist eye drops.
Method: Single-person case report.
Results: A 72-year-old lady with primary open angle glaucoma presented with a one year history of audible clicking sounds on eyelid closure. She had used bimatoprost 0.3% for three years followed by travoprost 0.004%/ timolol 0.5% for two years. On eye opening a small air bubble was momentarily visible under the left upper eyelid and on eyelid closure an audible click was heard (video). The ëclickí was cured with a 3 mm left mini-lateral tarsorrhaphy, and the patient remained symptom free at 32 months post-operatively.
Conclusion: Eyelid clicking secondary to prostaglandin agonists is previously unreported in the medical literature, although it is described on patient web-based medical forums. We have called this side effect ëblepharothoreviaí from the Greek†ëblepharoní (eyelid) and ëthoryvosí†(sound).