Robyn Guymer, Kate Brassington, Peter Dimitrov, Galina Makeyeva, Devinder Chauhan, Algis Vingrys, Chi Luu
To report on the early experience of nano-second laser application to the macula in participants with bilateral early age-related macular degeneration (AMD) who are participating in a pilot study.
50 participants received ultra-low energy laser pulses (Ellex 2RT laser) applied in 12 spots around the macula of one eye (0.15 mJ to 0.45 mJ), using 400 um diameter spot, 3 nanosecond pulse length, 532 nm wavelength, and energy titrated to each patient. Fundus images, best corrected visual acuity (BCVA), and macular perimetry were recorded at baseline, 3, 6, and 12 months post-laser.
Treatment was painless with no clinically visible lesions. Clinical changes were often seen in both the treated and untreated eye with drusen disap-pearance and BCVA improvements. Macular perime-try was used to monitor functional change over time with pre-treatment perimetry identifying discrete regions of reduced sensitivity, particularly in para-foveal regions. Functional improvements in areas of reduced sensitivity occurred between 3 & 6 months post treatment, and were maintained at 12 months.
A single unilateral application of nano-second laser to the macula produced bilateral improve-ments in macula appearance and visual function. The nanosecond 2RT laser warrants ongoing evaluation as an early intervention.