Priya D. Samalia, Joanne L. Sims, Narme Deva
Purpose: Idiopathic retinal vasculitis, aneurysms and neuroretinitis is a rare vision-threatening condition. If untreated vision loss occurs due to complications of pro- gressive retinal ischemia including retinal neovascularisation, neovascular glaucoma and retinal exudation. Despite the proposed underlying inflamma tory aetiology, this condition demonstrates poor response to corticosteroid treatment. We present two cases of idio- pathic retinal vasculitis, aneurysms and neuroretinitis successfully treated with infliximab.
Methods: Case reports of a 14-year old male and a 16-year old male, and review of relevant literature.
Results: Two paediatric cases of idiopathic retinal vasculitis, aneurysms and neuroretinitis that demonstrate anatomic and functional improvement with infliximab treatment.
Conclusion: Infliximab treatment led to resolution of aneurysmal dilatations and retinal vasculitis, and reversal of some retinal capillary non-perfusion. Early treatment with infliximab should be considered for any subject presenting with idiopathic retinal vasculitis, aneurysms and neuroretinitis.
Impact on surgical outcomes of primary vitrectomy for rhegmatogenous retinal detachment with and without the use of 360 degree laser retinopexy
Efficacy and safety of intravitreal pegcetacoplan in geographic atrophy: Results from the phase 3 DERBY and OAKS trials