ABSTRACT NUMBER - 117

IS ASPIRIN INTAKE ASSOCIATED WITH EARLY AGE-RELATED MACULAR DEGENERATION?


Ning Cheung, Wan-Ting Tay, Gemmy CM Cheung, Jie-Jin Wang, Paul Mitchell, Tien-Yin Wong,

Meeting:  2012 RANZCO


SESSION INFORMATION

Date:      -

Session Title: POSTER ABSTRACTS

Session Time:      -

Purpose: To examine the relationship between aspirin intake and early age-related macular degenera-tion (AMD) among an Asian population.

Methods:
A population-based, cross-sectional study of 3,207 ethnic Indians aged 40 years or older residing in Singapore. AMD signs were graded from retinal images following the modified Wisconsin grading system. Information on aspirin intake was obtained from a standardized questionnaire.

Results:
The prevalence of early AMD was 5.6%. Aspirin use was reported by 11.4% of participants. Early AMD signs were present among 10.9% of aspirin users and 4.9% of non-aspirin users (p < 0.001). After adjusting for potential confounders including age, smoking and previous cataract surgery, aspirin use was associated with early AMD (odds ratio [OR] 1.50; 95% confidence interval [CI]: 1.01, 2.22). The association was stronger and significant in participants with car-diovascular disease (adjusted OR 2.64, 95% CI: 1.31, 5.36) but not seen in those without a history of cardio-vascular disease (OR 0.73; 95% CI: 0.36, 1.51) (inter-action term, p = 0.011). Conclusions: Aspirin intake was associated with early AMD in this sample of Asian Indians with a history of cardiovascular disease. Further evaluation of the longitudinal relationship between aspirin use and progression of early to late AMD is warranted.