Belinda Leong1,2, K Bailey Freund1,2, David Sarraf3, Sean Garrity3, Kiran Vupparaboina4, Kunal Dansingani5,6
Purpose: To use optical coherence tomography angiography (OCTA) to evaluate the intra-retinal course of collateral vessels occurring in eyes with branch or hemispheric retinal vein occlusion (RVO) in order to demonstrate that retinal venous outﬂow may originate entirely in the deep vascular com- plex (DVC).
Methods: Observational retrospective review of OCTA data from eyes with branch or hemispheric RVO displaying collateral vessels within the mac- ula. Collaterals identiﬁed from fundus photography and/or ﬂuorescein angiography not involving the perifoveal vascular ring were analyzed to determine whether they coursed through the superﬁcial vascu- lar plexus (SVP), DVC, or both.
Results: From 23 eyes (21 branch, 1 hemispheric RVO) of 23 patients (mean age 73 11 years), 101 col- lateral vessels were identiﬁed and analyzed (mean 4.4 2.0, range: 2-9 collateral per eye). On OCTA, collat- erals appeared as curvilinear dilated ﬂow signals con- necting veins across the horizontal raphe or on opposite sides of an occluded venous segment within the same retinal hemisphere. Of 101 collaterals ana- lyzed, nearly all showed substantially greater ﬂow signal in the DVC, and all had some portion of their
course identiﬁed within the DVC.
Conclusions: Collateral vessels associated with branch/hemispheric RVO and identiﬁed outside the perifoveal capillary ring were all found to course through the DVC. The absence of collaterals con- ﬁned to the SVP suggests that venous drainage does not originate in the superﬁcial plexus. This may have important implications in understanding the pathogenesis underlying retinal vascular diseases such as paracentral acute middle maculopathy and other acute macular neuroretinopathies.
COMPARISON OF RANIBIZUMAB AND AFLIBERCEPT IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATED FOLLOWING A ?TREAT AND EXTEND? PROTOCOL: EFFICACY VARIABLES FROM THE PRE-SPECIFIED 12- MONTH INTERIM ANALYSIS OF THE RIVAL STUDY