Himanshu Wadhwa, Joanne L. Sims, Rachael L. Niedere
Aim: To examine the rate of recurrence of toxoplasmosis retinochoroiditis within a New Zealand population and to examine risk factors for recurrence.
Methods: Retrospective observational case series of all subjects with toxoplasmosis retinochoroiditis presenting to Auckland District Health Board Department of Oph- thalmology between 2006 – 2019.
Results: A total of 115 subjects were included with a median age at initial diagnosis of 36.7 years (interquartile range 23.7 to 53.8). 16 subjects (13.9%) were immunosuppressed. 30.2% (26 subjects out of the 82 subjects who had serology performed) were IgM-positive at presentation. Mean follow up was 6.1 years per person. Seventy- three recurrences occurred during follow up in 36 subjects (31.3%). 88.4% of cases were treated with oral antibiotics. After treatment, most immunosuppressed subjects also received prophylactic antibiotics. Recurrence occurred in 14.8% in the first year (95% confidence interval 10.3% – 21.0%) and risk of recurrence was increased by 2x for every previous documented recurrence (p < 0.001). There was no statistically significant increased risk of recurrence with age, IgM-positivity, macular involvement or immunosuppression. Conclusions: Toxoplasmosis had a 14.8% risk of recurrence in the first year, with each previous recurrence increasing the risk by 2x.
Impact on surgical outcomes of primary vitrectomy for rhegmatogenous retinal detachment with and without the use of 360 degree laser retinopexy
Efficacy and safety of intravitreal pegcetacoplan in geographic atrophy: Results from the phase 3 DERBY and OAKS trials