Belinda Leong1,2,3, Serena Fragiotta1,4,2,3, Talia Kaden1,3,5, K. Bailey Freund1,3,2, Michael Engelbert1,3,2
Purpose: To examine the posterior vitreous of healthy subjects using Swept-Source Optical Coher- ence Tomography (SS-OCT) and characterize the topographic relations of the premacular bursa, prevas- cular vitreous ﬁssures (PVFs), lacunae and cisterns.
Methods: PLEXTM Elite 9000 SS-OCT (Carl Zeiss Meditec) was used to acquire 12 × 12 mm (1024 × 1024) cube scans. 37 eyes of healthy subjects aged 7.2-35.5 years old with an axial range of 23.0-26.6 mm were examined. Vitreous scans were segmented parallel to the vitreoretinal interface. En- face and cross-sectional images were correlated.
Results: En-face and cross-sectional B-scans con- ﬁrmed that, in the majority (97.3%) of patients, the premacular bursa and prepapillary gap connect at a variable distance from the optic nerve superiorly and follow a common course anteriorly in a supero- nasal direction. The course of prevascular ﬁssures (PVFs) could be determined with respect to the appearance and structure of cisternal spaces. The morphology of and differences between cisterns and lacunae were also characterized. Degenerative, eyewall-parallel ﬁssure planes and their course are described for the ﬁrst time in a three-dimensional manner. In a small number of patients (37.8%), these ﬁssure planes were noted to arise from PVFs with a signiﬁcantly different morphology.
Conclusions: The en-face vitreous SS-OCT scans obtained are of unprecedented resolution and depth and unequivocally reveal the topographic relation- ships of vitreous hyporeﬂective spaces. They conﬁrm the anterior course of the premacular bursa and Clo- quet’s canal and the connection between the two.
COMPARISON OF RANIBIZUMAB AND AFLIBERCEPT IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATED FOLLOWING A ?TREAT AND EXTEND? PROTOCOL: EFFICACY VARIABLES FROM THE PRE-SPECIFIED 12- MONTH INTERIM ANALYSIS OF THE RIVAL STUDY