Mona S Awadalla1, Bronwyn Usher1, Jude Fitzgerald1, John Landers1, Geoff Pollard2, Alex W Hewitt3, David A Mackey4, Jamie E Craig1
Objective: The aim of this study was to determine the prevalence of open angle glaucoma (OAG), and glaucoma suspect status in first-degree relatives of patients with advanced OAG, and to evaluate the reliability of a reported family history of glaucoma within these pedigrees.
Method: One hundred index cases based in South Australia were selected at random from all available advanced glaucoma cases in the ANZRAG. Each living first-degree relative aged over 40 years was then invited to participate in a screening evaluation. All participants had an eye examination including; visual acuity, refraction, slit-lamp biomicroscopy, intraocular pressure (IOP), optic disc stereophotography, OCT, and automated visual field perimetry. Participants were classified either as normal (IOP /=22 mm Hg and/or suspicious optic disc); or POAG (field defect and glaucomatous optic disc).
Results: To date, 104 subjects from 76 families have agreed to participate in the study, and 85 first-degree relatives have attended the screening examination. 21 (25%) were diagnosed or confirmed to have definite OAG, and 20 (23%) were identified as glaucoma suspects. 44 (52%) participants were normal, and 19 (18%) subjects declined to take part in the study.
Conclusions: The eye examination of first-degree relatives of advanced glaucoma cases identified or confirmed that almost half of these at risk individuals are affected or show some signs of glaucoma. Despite being close relatives of advanced glaucoma patients, 19% of those approached declined to take part.
COMPARISON OF RANIBIZUMAB AND AFLIBERCEPT IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATED FOLLOWING A ?TREAT AND EXTEND? PROTOCOL: EFFICACY VARIABLES FROM THE PRE-SPECIFIED 12- MONTH INTERIM ANALYSIS OF THE RIVAL STUDY