ABSTRACT NUMBER - 1306

TOPICAL ATORVASTATIN FOR THE TREATMENT OF DRY EYE ASSOCIATED WITH BLEPHARITIS


Kenneth G-J Ooi, Denis Wakefield,Frank A Billson, Stephanie L Watson

Meeting:  2013 RANZCO


SESSION INFORMATION

Date: 04 Nov 2013

Session Title: SYMPOSIUM

Session Time: 2:00 pm - 3:30 pm

Purpose:
To investigate topical Atorvastatin, a novelocular therapy, for patients with dry eye associatedwith blepharitis.

Method:
10 patients with symptoms and signs of dryeye and blepharitis were enrolled in a prospective pilotstudy of topical Atorvastatin therapy over 1 month.The primary outcome measure was corneal fluoresceinstaining.

Results: An improvement in corneal fluoresceinstaining ?1 by point from baseline to completion of thetrial at week four was found in 9 of 10 patients(p = 0.007) and ?3 points in 6 of 10 patients in the studyeye. Topical statin significantly improved the blepharitisscore (p = 0.011) and the tear film break-up time(p = 0.005). Subjective dry eye symptoms improved(p = 0.005). There were no adverse events.

Conclusion:
Topical Atorvastatin is a potential safetherapy for patients with dry eye and blepharitis. Itmay also be of benefit in other dry eye syndromes.

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